Document Detail


Silymarin inhibits melanin synthesis in melanocyte cells.
MedLine Citation:
PMID:  19406006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim was to search for inhibitors of melanogenesis from natural resources. METHODS: The inhibitory effect of silymarin on melanogenesis in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab, was studied. KEY FINDINGS: Silymarin significantly prevented melanin production in a dose-dependent manner with an IC50 value (concentration producing 50% maximal inhibition) of 28.2 microg/ml, without effects on cell viability. Also, silymarin inhibited L-DOPA oxidation activity of tyrosinase, the rate-limiting melanogenic enzyme, in cell based-systems but it did not directly affect cell-free tyrosinase activity. Furthermore, Western blot analysis indicated that silymarin decreased the expression of tyrosinase protein. CONCLUSIONS: This study suggests that the depigmenting effect of silymarin might be attributable to inhibition of tyrosinase expression and that silymarin may be useful as a natural skin-lightening agent.
Authors:
Soo-Jin Choo; In-Ja Ryoo; Young-Hee Kim; Guang-Hwa Xu; Won-Gon Kim; Ki-Ho Kim; Seong-Joon Moon; Eui-Dong Son; KiHwan Bae; Ick-Dong Yoo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  61     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  663-7     Citation Subset:  IM    
Affiliation:
Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Blotting, Western
Cell Line
Cell Survival / drug effects
Levodopa / metabolism
Melanins / antagonists & inhibitors*,  biosynthesis*
Melanocytes / drug effects*,  metabolism
Mice
Monophenol Monooxygenase / antagonists & inhibitors,  biosynthesis
Silymarin / pharmacology*
Skin Pigmentation / drug effects
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Levodopa; 0/Melanins; 0/Silymarin; EC 1.14.18.1/Monophenol Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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