| Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity. | |
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MedLine Citation:
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PMID: 22476383 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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[Ag(2)(9-aca)(2)] () (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)(2.3)(CH(3)CN)(0.7)](9-aca) (), [Ag(6)(imidH)(4)(9-aca)(6)(MeOH)(2)] (), {[Ag(1-Me-imid)(2)](2)[Ag(4)(9-aca)(6)]} (), {[Ag(1-Bu-imid)(2)](2)[Ag(4)(9-aca)(6)]} () and [Ag(apim)](9-aca)·H(2)O () (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex , hexanuclear , and polymeric , were all characterised using X-ray crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can survive high doses of the Ag(i) complexes administered in vivo, and a number of the complexes offer significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells. |
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Authors:
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Malachy McCann; Robert Curran; Marcia Ben-Shoshan; Vickie McKee; Asif Ali Tahir; Michael Devereux; Kevin Kavanagh; Bernadette S Creaven; Andrew Kellett |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-5 |
Journal Detail:
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Title: Dalton transactions (Cambridge, England : 2003) Volume: - ISSN: 1477-9234 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101176026 Medline TA: Dalton Trans Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, National University of Ireland, Maynooth, Co. Kildare, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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