Document Detail

Silver-stained nucleolar organizer regions and immunoglobulins in cutaneous squamocellular tumors.
MedLine Citation:
PMID:  17949923     Owner:  NLM     Status:  MEDLINE    
This study was conducted to elucidate the biological activity of epidermal cells in cutaneous squamocellular tumors by counting the number of silver-stained nucleolar organizer regions (AgNORs), to estimate the quantity of Ig-producing cells and the inflammatory cellular infiltrate (ICI), and to achieve a comparative evaluation. Twenty cases of actinic keratosis (AK), 20 in situ squamous cell carcinomas (ISC), and 20 invasive squamous cell carcinomas (SCCs) were assessed using a silver colloid technique. Ig-producing or binding cells and ICI were also investigated immunohistochemically. In all samples, AgNORs, Ig-producing cells, and ICI increased in proportion to the degree of malignancy. With regard to AgNORs values, a statistically significant difference was confirmed between AK and ISC (p<0.01), AK and SCC (p<0.001), and ISC and SCC (p<0.05). IgG-producing cells predominated in each case. Furthermore, a linear correlation was detected between ICI and AgNORs in AK and ISC. The significant difference in the number of AgNORs among the 3 stages of involution of SCC reinforces the value of AgNORs as a marker for malignant potential. Despite the absence of a correlation between AgNORs and the proportion of Ig-producing cells, the association between ICI and AgNORs in AK and ISC was obvious.
Kiriaki Aroni; Aikaterini Mastoraki; Evridiki Kyriazi; Anna Liossi; Eleftherios Ioannidis
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Publication Detail:
Type:  Journal Article     Date:  2007-10-18
Journal Detail:
Title:  Pathology, research and practice     Volume:  203     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  857-62     Citation Subset:  IM    
Department of Dermatopathology, University of Athens, 75 Mikras Asias Street, GR-11527 Athens, Greece.
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MeSH Terms
Antigens, Nuclear*
Carcinoma in Situ / metabolism,  pathology*
Carcinoma, Squamous Cell / metabolism,  pathology*
Immunoglobulins / metabolism*
Keratosis / metabolism,  pathology*
Nuclear Proteins*
Nucleolus Organizer Region / pathology*
Precancerous Conditions / metabolism,  pathology*
Silver Staining / methods
Skin Neoplasms / metabolism,  pathology*
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Antigens, Nuclear; 0/Immunoglobulins; 0/Nuclear Proteins; 0/Tumor Markers, Biological; 0/nucleolar organizer region associated proteins

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