Document Detail

Silver sulfadiazine nanosystems for burn therapy.
MedLine Citation:
PMID:  23274734     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to formulate stable silver sulfadiazine (SSD) nanosuspensions and nanogels suitable for topical delivery with a view to increase bactericidal activity in burn therapy. SSD nanosuspensions were formulated using the microprecipitation-high-pressure homogenization technique. An optimized microsuspension of 0.5% SSD formulated with 6% Cremophor EL and 4% Lauroglycol 90 was subjected to 30 cycles of 1,000-bar pressure to give a nanosuspension with an average particle size of 367.85 nm. Transmission electron microscopy studies revealed that ovoid- to rectangular-shaped SSD particles were present as clusters. It was evident through X-ray diffraction studies that SSD was present in amorphous state both in microprecipitate and in nanosuspension. SSD (0.5%) nanogels were prepared using 1% Carbopol 974 P for topical delivery of nanosized SSD. In vitro release studies demonstrated that SSD release was faster from solutions and nanosuspensions compared to gel formulation owing to the influence of the gel matrix on SSD release. The bacterial inhibitory efficiency of SSD nanosuspension was as good as that of SSD solution against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In vivo studies revealed that a nanogel containing 0.5% SSD was more effective in wound healing compared to 0.5% and 1% marketed cream.
Meenakshi Venkataraman; Mangal Nagarsenker
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Publication Detail:
Type:  Journal Article     Date:  2012-12-29
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-12     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-64     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / chemistry,  therapeutic use*
Burns / drug therapy*
Microbial Sensitivity Tests
Microscopy, Electron, Transmission
Silver Sulfadiazine / chemistry,  therapeutic use*
X-Ray Diffraction
Reg. No./Substance:
0/Anti-Bacterial Agents; W46JY43EJR/Silver Sulfadiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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