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Silicosis and coal workers' pneumoconiosis.
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MedLine Citation:
PMID:  10931786     Owner:  NLM     Status:  MEDLINE    
Exposure to coal mine dust and/or crystalline silica results in pneumoconiosis with initiation and progression of pulmonary fibrosis. This review presents characteristics of simple and complicated coal workers' pneumoconiosis (CWP) as well as pathologic indices of acute and chronic silicosis by summarizing results of in vitro, animal, and human investigations. These results support four basic mechanisms in the etiology of CWP and silicosis: a) direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring; b) activation of oxidant production by pulmonary phagocytes, which overwhelms the antioxidant defenses and leads to lipid peroxidation, protein nitrosation, cell injury, and lung scarring; c) activation of mediator release from alveolar macrophages and epithelial cells, which leads to recruitment of polymorphonuclear leukocytes and macrophages, resulting in the production of proinflammatory cytokines and reactive species and in further lung injury and scarring; d) secretion of growth factors from alveolar macrophages and epithelial cells, stimulating fibroblast proliferation and eventual scarring. Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms.
V Castranova; V Vallyathan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  108 Suppl 4     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-10-23     Completed Date:  2000-10-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  675-84     Citation Subset:  IM    
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
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MeSH Terms
Air Pollutants, Occupational / adverse effects*
Pneumoconiosis / etiology*
Silicosis / etiology
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Coal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 8 Year: 2000
Volume: 108 Issue: Suppl 4
First Page: 675 Last Page: 684
ID: 1637684
PubMed Id: 10931786
Publisher Item Identifier: sc271_5_1835

Silicosis and coal workers' pneumoconiosis.
V Castranova
V Vallyathan
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.

Article Categories:
  • Research Article

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