| Silicone-coated non-woven polyester dressing enhances reepithelialisation in a sheep model of dermal wounds. | |
MedLine Citation:
|
PMID: 22692367 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Negative-pressure wound therapy (NPWT) also known as V.A.C. (Vacuum-assisted closure), is widely used to manage various type of wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane (PU) foam or medical gauze. In this study an experimental setup of sheep wound model was used to evaluate, under NPWT conditions, the performance of a silicone-coated non-woven polyester (N-WPE) compared with PU foam and cotton hydrophilic gauze, used as reference materials. Animals were anesthetized with spontaneous breathing to create three 3 × 3 cm skin defects bilaterally; each animal received three different samples on each side (n = 6 in each experimental group) and was subjected to negative and continuous 125 mmHg pressure up to 16 days. Wound conditions after 1, 8 and 16 days of treatment with the wound dressings were evaluated based on gross and histological appearances. Skin defects treated with the silicone-coated N-WPE showed a significant decrease in wound size, an increase of re-epithelialization, collagen deposition and wound neovascularisation, and a minimal stickiness to the wound tissue, in comparison with gauze and PU foam. Taken all together these findings indicate that the silicone-coated N-WPE dressing enhances wound healing since stimulates higher granulation tissue formation and causes minor tissue trauma during dressing changes. |
Authors:
|
Paola Losi; Enrica Briganti; Manolo Costa; Elena Sanguinetti; Giorgio Soldani |
Related Documents
:
|
17371527 - Effects of thalidomide on isoprenaline-induced acute myocardial injury: a haemodynamic,... 22685047 - Dark chocolate for children's blood pressure: randomised trial. 41057 - Haemodynamic effects of the carboxylic ionophore monensin when administered before and ... 22829927 - Lung function and breathing pattern in subjects developing high altitude pulmonary edema. 2736757 - Volume-pressure analysis of reflex changes in forearm venous function. a method by ment... 22611097 - Ultrahigh-pressure experiment with a motor-driven diamond anvil cell. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-13 |
Journal Detail:
|
Title: Journal of materials science. Materials in medicine Volume: - ISSN: 1573-4838 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Laboratory for Biomaterials and Graft Technology, Institute of Clinical Physiology (CNR), via Aurelia Sud, 54100, Massa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis and reactivity of a conveniently prepared two-coordinate bis(amido) nickel(ii) complex.
Next Document: A photoresponsive Au(25) nanocluster protected by azobenzene derivative thiolates.