Document Detail


Silicon carbide-coated stents: clinical experience in coronary lesions with increased thrombotic risk.
MedLine Citation:
PMID:  9497204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To report the results of a prospective, nonrandomized, multicenter study of a semiconductor-coated stent in coronary lesions at high risk for stent thrombosis. METHODS: A balloon-expandable tantalum stent was coated with silicon carbide to enhance thromboresistance (Tensum). Patients were enrolled in an observational study that compared coronary stenting with the Tensum stent in patients at low risk for stent thrombosis against those with factors predisposing to local thrombosis (acute myocardial infarction, small vessel diameter, recanalized chronic total occlusion, saphenous vein bypass grafts, and coronary allograft vascular disease). RESULTS: In 294 patients with 364 coronary lesions, 111 patients with 142 lesions were assigned to the high-risk group. Overall, 406 Tensum stents were implanted (94% procedural success) using antiplatelet medication only after the procedure. The stent thrombosis rate (2.7% overall) in the high-risk group (3.6%) was not significantly different from that of the low-risk patients (2.1%). CONCLUSIONS: Silicon carbide coating on coronary stents may inhibit acute/subacute stent thrombosis even in patients at high risk. Randomized trials are underway for further evaluation of this promising coated stent.
Authors:
B Heublein; C Ozbek; K Pethig
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery     Volume:  5     ISSN:  1074-6218     ISO Abbreviation:  J Endovasc Surg     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-23     Completed Date:  1998-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9500580     Medline TA:  J Endovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  IM    
Affiliation:
Hannover Medical School, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angioplasty, Balloon
Carbon Compounds, Inorganic
Coronary Disease / therapy*
Coronary Thrombosis / prevention & control*
Equipment Design
Female
Fibrinolytic Agents / therapeutic use
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Silicon Compounds
Stents*
Ticlopidine / therapeutic use
Chemical
Reg. No./Substance:
0/Carbon Compounds, Inorganic; 0/Fibrinolytic Agents; 0/Silicon Compounds; 409-21-2/silicon carbide; 55142-85-3/Ticlopidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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