| Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. | |
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MedLine Citation:
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PMID: 19950973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging of hyperpolarized nuclei provides high image contrast with little or no background signal. To date, in vivo applications of prehyperpolarized materials have been limited by relatively short nuclear spin relaxation times. Here, we investigate silicon nanoparticles as a new type of hyperpolarized magnetic resonance imaging agent. Nuclear spin relaxation times for a variety of Si nanoparticles are found to be remarkably long, ranging from many minutes to hours at room temperature, allowing hyperpolarized nanoparticles to be transported, administered, and imaged on practical time scales. Additionally, we demonstrate that Si nanoparticles can be surface functionalized using techniques common to other biologically targeted nanoparticle systems. These results suggest that Si nanoparticles can be used as a targetable, hyperpolarized magnetic resonance imaging agent with a large range of potential applications. |
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Authors:
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Jacob W Aptekar; Maja C Cassidy; Alexander C Johnson; Robert A Barton; Menyoung Lee; Alexander C Ogier; Chinh Vo; Melis N Anahtar; Yin Ren; Sangeeta N Bhatia; Chandrasekhar Ramanathan; David G Cory; Alison L Hill; Ross W Mair; Matthew S Rosen; Ronald L Walsworth; Charles M Marcus |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: ACS nano Volume: 3 ISSN: 1936-086X ISO Abbreviation: ACS Nano Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-22 Completed Date: 2010-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101313589 Medline TA: ACS Nano Country: United States |
Other Details:
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Languages: eng Pagination: 4003-8 Citation Subset: IM |
Affiliation:
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Department of Physics, Harvard University, Cambridge, MA 02138, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media
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chemistry* Crystallization / methods Image Enhancement / methods* Macromolecular Substances / chemistry Magnetic Resonance Imaging / instrumentation, methods* Materials Testing Molecular Conformation Nanomedicine / methods Nanostructures / chemistry*, diagnostic use*, ultrastructure Particle Size Silicon / chemistry* Surface Properties Titanium / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA124427/CA/NCI NIH HHS; R21 EB007486-01A1/EB/NIBIB NIH HHS; U54 CA119335/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Macromolecular Substances; 13463-67-7/titanium dioxide; 7440-21-3/Silicon; 7440-32-6/Titanium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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