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MedLine Citation:
PMID:  23150623     Owner:  NLM     Status:  Publisher    
PURPOSE: TO INVESTIGATE COMPOSITIONS OF SILICA-COLLAGEN HYBRID MATERIALS AS POTENTIAL ARTIFICIAL CORNEAL SUBSTITUTES, AND HOW THESE COMPONENTS AFFECT THE OPTICAL AND BIOMECHANICAL PROPERTIES OF THE HYBRIDS, AND THEIR BIOCOMPATIBILITY IN AN ORGAN CULTURE MODEL. METHODS: Hybrid materials were created from different proportions of collagen and silica precursors, and manufactured to specific dimensions. The microstructure of the materials was determined by electron microscopy and mechanical strength was measured by using suture pullout tests. The refractive index and transmittance were measured by using an Abbe refractometer and a spectrophotometer. Materials were implanted into rabbit corneas to determine their epithelialization in organ culture. RESULTS: Scanning electron microscopy demonstrated that the hybrid material consisted of silica encapsulating collagen fibrils. The refractive index ranged from 1.332 to 1.403 depending upon the composition and manufacturing characteristics. The rupture strength of a 3:1 (silica: collagen ratio by weight) rehydrated xerogel was 0.161 ± 0.073 N/mm (n=12). Re-epithelialization of 5-6 mm-wide rabbit corneal epithelial defects was complete in 5.5 ± 2.4 days (n=6), with evidence of epithelial stratification. CONCLUSIONS: Silica-collagen hybrid materials can be manufactured to specific dimensions to serve as a possible artificial corneal substitute. In preliminary studies, the materials have favorable optical, biomechanical, and biocompatibility properties necessary for replacing the corneal stroma.
Michael D Divito; Stephen G Rudisill; Andreas Stein; Sanjay V Patel; Jay W McLaren; Allison Hubel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, United States.
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