Document Detail

Silica gel is as effective as acyclovir cream in patients with recurrent herpes labialis: results of a randomized, open-label trial.
MedLine Citation:
PMID:  18569274     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare silica gel with acyclovir cream in the treatment of recurrent herpes labialis. METHODS: In this randomized, open-label, comparator-controlled trial, 74 patients with recurrent herpes labialis applied silica gel or acyclovir cream respectively over a period of 10 days. The treatment started within 24 hours of the first symptoms of a new recurrence. Patients rated five symptoms (tautness, tingling, itching, burning sensation, pain), lesion stage, efficacy, tolerability, and duration until the onset of improvement. Their willingness-to-pay was assessed. Physicians rated the severity of the herpes recurrence and efficacy. RESULTS: There was no significant difference between silica gel and acyclovir cream in the overall patients' assessment. There is evidence that silica gel relieved all investigated symptoms earlier than acyclovir cream. The efficacy and tolerability of both medications were rated as good to very good. CONCLUSIONS: Silica gel was as effective in the treatment of recurrent herpes labialis as acyclovir and equally well tolerated and tended to take effect more quickly. Therefore, silica gel could prove a useful alternative to topical acyclovir.
Ina Zschocke; Christine Reich; Andrea Zielke; Nadja Reitmeier; Kristian Reich
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  19     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  176-81     Citation Subset:  IM    
SCIderm Institute for Clinical Research, Hamburg, Germany.
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MeSH Terms
Acyclovir / administration & dosage*,  adverse effects
Administration, Topical
Antiviral Agents / administration & dosage*,  adverse effects
Dermatologic Agents / administration & dosage*,  adverse effects
Herpes Labialis / complications,  drug therapy*,  pathology
Lip / pathology
Middle Aged
Pain / etiology
Patient Satisfaction / economics
Pruritus / etiology
Severity of Illness Index
Silicon Dioxide / administration & dosage*,  adverse effects
Treatment Outcome
Reg. No./Substance:
0/Antiviral Agents; 0/Dermatologic Agents; 0/Gels; 59277-89-3/Acyclovir; 60650-90-0/silochrome; 7631-86-9/Silicon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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