| Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 19900758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic ethanol consumption is a known risk factor for developing hepatocellular carcinoma (HCC). The use of plant-derived antioxidants is gaining increasing clinical prominence as a potential therapy to ameliorate the effects of ethanol on hepatic disease development and progression. This study demonstrates silibinin, a biologically active flavanoid derived from milk thistle, inhibits cytochrome p4502E1 induction, ethanol metabolism and reactive oxygen species generation in HCC cells in vitro. These silibinin-mediated effects also inhibit ethanol-dependent increases in HCC cell proliferation in culture. |
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Authors:
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Elizabeth Brandon-Warner; James A Sugg; Laura W Schrum; Iain H McKillop |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-08 |
Journal Detail:
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Title: Cancer letters Volume: 291 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-04-16 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 120-9 Citation Subset: IM |
Copyright Information:
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2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Biology, The University of North Carolina at Charlotte, 28223, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Carcinoma, Hepatocellular / metabolism, pathology* Cell Line, Tumor Cell Proliferation / drug effects Cytochrome P-450 CYP2E1 / genetics Ethanol / metabolism, pharmacology* Lipid Peroxidation / drug effects Liver Neoplasms, Experimental / metabolism, pathology* Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Rats Reactive Oxygen Species / metabolism Silymarin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AA016858/AA/NIAAA NIH HHS; R21 AA016858-01A2/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Reactive Oxygen Species; 0/Silymarin; 22888-70-6/silybin; 64-17-5/Ethanol; EC 1.14.14.1/Cytochrome P-450 CYP2E1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3 |
| Comments/Corrections | |
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