| Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells. | |
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MedLine Citation:
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PMID: 19968587 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The pharmacological activity of polyphenolic silibinin from milk thistle (Silybum marianum) is primarily due to its antioxidant property. However, this study found that silibinin promoted sustained superoxide (O(2)(.-)) production that was specifically scavenged by exogenous superoxide dismutase (SOD) in MCF-7 cells, while the activity of endogenous SOD was not changed by silibinin. Previous work proved that silibinin induced MCF-7 cell apoptosis through mitochondrial pathway and this study further proved that O(2)(.-) generation induced by silibinin was also related to mitochondria. It was found that respiratory chain complexes I, II and III were all involved in silibinin-induced O(2)(.-) generation. Moreover, it was found that silibinin-induced O(2)(.-) had protective effect, as exogenous SOD markedly enhanced silibinin-induced apoptosis. |
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Authors:
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Hong-Jun Wang; Yuan-Yuan Jiang; Xiao-Feng Wei; Huai Huang; Shin-Ichi Tashiro; Satoshi Onodera; Takashi Ikejima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Free radical research Volume: 44 ISSN: 1029-2470 ISO Abbreviation: Free Radic. Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 90-100 Citation Subset: IM |
Affiliation:
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China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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