| Silent thyroiditis with thyroid-stimulation-blocking antibodies (TSBAb). | |
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MedLine Citation:
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PMID: 1983199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 24-year-old man showed thyrotoxic symptoms with hypokalemic periodic paralysis. Serum thyroid hormone levels were high and thyrotropin (TSH) was undetectable. 123I-thyroidal uptake was suppressed. TSH-binding inhibitor immunoglobulin (TBII) was positive. After a month without any treatment, he became hypothyroid. Thyroid hormone level was decreased and TSH was increased to above the normal range. 123I-thyroidal uptake was increased. TBII activity was still positive. From the clinical findings, a diagnosis of silent thyroiditis was made. Sera obtained in the hypothyroid state revealed the presence of thyroid-stimulation-blocking antibodies (TSBAb), but there were no thyroid-stimulating antibodies (TSAb). These results suggest that the hypothyroidism in this patient was due to the presence of TSBAb with TBII activity. |
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Authors:
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S Nakamura; M Sugimoto; J Kosaka; H Watanabe; H Shima; S Kawahira |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Japanese journal of medicine Volume: 29 ISSN: 0021-5120 ISO Abbreviation: Jpn. J. Med. Publication Date: 1990 Nov-Dec |
Date Detail:
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Created Date: 1991-09-11 Completed Date: 1991-09-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0247713 Medline TA: Jpn J Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 623-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Gifu Red Cross Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / analysis*, immunology Humans Hypokalemia / etiology Hypothyroidism / blood, etiology Immunoglobulins, Thyroid-Stimulating Iodine Radioisotopes / diagnostic use Male Paralysis / etiology Thyroid Hormones / blood Thyroiditis, Autoimmune / blood, complications, diagnosis, immunology* Thyrotoxicosis / blood, etiology Thyrotropin / blood*, deficiency, immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulins, Thyroid-Stimulating; 0/Iodine Radioisotopes; 0/Thyroid Hormones; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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