| Silent pulmonary embolism in patients with deep venous thrombosis: a systematic review. | |
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MedLine Citation:
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PMID: 20399319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine, by systematic review of the literature, the prevalence of silent pulmonary embolism in patients with deep venous thrombosis. METHODS: Twenty-eight included published investigations were identified through PubMed. Studies were selected if methods of diagnosis of pulmonary embolism were described; if pulmonary embolism was stated to be asymptomatic; and if raw data were presented. Studies were stratified according to whether silent pulmonary embolism was diagnosed by a high-probability ventilation-perfusion lung scan using criteria from the Prospective Investigation of Pulmonary Embolism Diagnosis, computed tomography pulmonary angiography, or conventional pulmonary angiography (Tier 1), or by lung scans based on non-Prospective Investigation of Pulmonary Embolism Diagnosis criteria (Tier 2). RESULTS: Silent pulmonary embolism was diagnosed in 1665 of 5233 patients (32%) with deep venous thrombosis. This is a conservative estimate because many of the investigations used stringent criteria for the diagnosis of pulmonary embolism. The incidence of silent pulmonary embolism was higher with proximal deep venous thrombosis than with distal deep venous thrombosis. Silent pulmonary embolism seemed to increase the risk of recurrent pulmonary embolism: 25 of 488 (5.1%) with silent pulmonary embolism versus 7 of 1093 (0.6%) without silent pulmonary embolism. CONCLUSION: Silent pulmonary embolism sometimes involved central pulmonary arteries. Because approximately one third of patients with deep venous thrombosis have silent pulmonary embolism, routine screening for pulmonary embolism may be advantageous. |
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Authors:
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Paul D Stein; Fadi Matta; Muzammil H Musani; Benjamin Diaczok |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of medicine Volume: 123 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-04-29 Revised Date: 2011-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
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Languages: eng Pagination: 426-31 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Departments of Internal Medicine, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA. steinp@trinity-health.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Pulmonary Embolism / complications, diagnosis* Venous Thrombosis / complications* |
| Comments/Corrections | |
Comment In:
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Am J Med. 2010 Dec;123(12):e15. author reply e17
[PMID:
20961520
]
Am J Med. 2011 Jan;124(1):e15; author reply e17 [PMID: 20934671 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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