Document Detail

Silent otitis media: an animal study.
MedLine Citation:
PMID:  6712087     Owner:  NLM     Status:  MEDLINE    
Recent clinical and laboratory observations suggest that otitis media can occur in the absence of visible tympanic membrane changes (silent otitis media). Temporal bone histopathology was studied in 38 chinchillas that had been subjected to conditions known to predispose these animals to otitis media. Morphological changes were compared to a control group of 25 nonmanipulated animals. The tympanic membranes were examined at intervals and during the immediate premortem period with the operating microscope. Thirty-one tympanic membranes in the experimental group and all tympanic membranes in the control group were judged to be normal (gray and translucent) throughout the study period. The middle ears from the experimental group histologically manifested varying amounts of effusion, mucosal edema, granulation tissue, hyperemia of the subepithelial space, hemorrhage in the middle ear space, and abundant polymorphonuclear leukocytes in the middle ear cleft. These findings were not present in the control group.
W L Meyerhoff; G S Giebink; D A Shea
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  93     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:    1984 Mar-Apr
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  136-9     Citation Subset:  AIM; IM    
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MeSH Terms
Otitis Media / pathology*
Temporal Bone / pathology
Tympanic Membrane / anatomy & histology,  pathology*
Grant Support

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