Document Detail


Silent myocardial ischemia after acute myocardial infarction.
MedLine Citation:
PMID:  1543137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Silent ischemia after myocardial infarction has definite prognostic significance but should be interpreted within the context of other prognostic indicators. The rationale for therapeutic intervention is based on the prognostic implications of silent ischemia and the potentially deleterious effect of repeated episodes of ischemia on the integrity of the left ventricle. We measured parameters of ischemia in 20 patients who showed asymptomatic ischemic ST-T changes on exercise testing in the early phase after myocardial infarction. After diltiazem administration, a reduction of exercise-induced ST-T depression from 2.3 +/- 0.8 to 0.7 +/- 0.6 mm (p less than 0.01) occurred, and regional wall-motion score at exercise, determined by radionuclide angiography, improved significantly (p less than 0.02). These and other observations warrant further studies in which the duration, severity and frequency of the ischemic episodes should be quantified and correlated with prognosis after myocardial infarction.
Authors:
E E Van der Wall; V Manger Cats; A V Bruschke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  69     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-09     Completed Date:  1992-04-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19B-24B     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, University Hospital, Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Coronary Disease / complications,  diagnosis*,  drug therapy
Diltiazem / therapeutic use
Electrocardiography
Exercise Test
Humans
Myocardial Infarction / complications,  physiopathology*
Prognosis
Chemical
Reg. No./Substance:
42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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