| Silent myocardial ischaemia in the elderly. | |
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MedLine Citation:
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PMID: 10917075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery disease (CAD) is a leading cause of death and disability in the elderly. Several recent studies have shown that silent myocardial ischaemia (SMI) is a common manifestation of CAD, especially in the elderly. As many as 40% of elderly patients with no prior history of CAD may have underlying asymptomatic disease and up to 50% of elderly patients with known CAD might have evidence of SMI. The results of studies in elderly patients with CAD have also shown that SMI might exist despite antianginal therapy that is considered adequate for symptom control. In order to diagnose such residual SMI, the clinician would need to perform 24- to 48-hour Holter monitoring in the ambulatory setting while the patient is performing routine daily activities. Although a number of anti-ischaemic drugs have been evaluated for the treatment of SMI, available data suggest that beta-blocker given alone or in combination with a nitrate compound or calcium antagonist provides the best therapeutic choice. The long term benefit of SMI suppression in elderly patients has not been established. Future studies need to evaluate the clinical benefits of therapy given for SMI in the elderly. |
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Authors:
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P C Deedwania |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs & aging Volume: 16 ISSN: 1170-229X ISO Abbreviation: Drugs Aging Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-11-13 Completed Date: 2000-11-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9102074 Medline TA: Drugs Aging Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 381-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, VA Central California Healthcare System/UCSF Program, Fresno, California 93703,USA. deed@ucsfresno.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Humans Myocardial Ischemia / diagnosis, drug therapy*, epidemiology Prevalence Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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