| Silent corticotroph adenomas have unique recurrence characteristics compared with other nonfunctioning pituitary adenomas. | |
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MedLine Citation:
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PMID: 19650787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The prevalence of silent corticotroph adenomas (SCAs) is not rare among nonfunctioning pituitary adenomas (NFPAs); however, it is unknown whether the clinical significance of SCAs differs from that of NFPAs without ACTH immunoreactivity (non-SCAs). Our goal was to compare the clinical characteristics and natural history between patients with SCAs and non-SCAs. DESIGN/PATIENTS: We reviewed the medical records of all patients who underwent transsphenoidal surgery for NFPAs from January 1990 to October 2007 at the Seoul National University Hospital. MEASUREMENTS: We analysed whether clinical manifestations at diagnosis, postoperative recurrence rate and recurrence characteristics differed between SCA and non-SCA patients. RESULTS: In total, 28 patients with SCAs and 134 patients with non-SCAs were analysed. The mean age at the time of diagnosis was 44 years (range, 13-67 years) in the SCA group and 50 years (18-79 years) in the non-SCA group (P = 0.026), with respective follow-up periods of 5.2 (range, 1.0-16.0 years) and 4.2 years (0.5-16.1 years) (P = 0.255). Overall recurrence rates of SCAs and non-SCAs were 25.0% and 26.9% respectively (P = 0.839). More than two recurrences (P = 0.001) and recurrence after more than 5 years (P = 0.040) were associated with SCAs. Multiple recurrences of SCAs were confined to younger patients. CONCLUSION: The overall recurrence rate was similar between SCAs and non-SCAs. However, young patients with SCAs had a higher frequency of multiple and late recurrences, which showed more aggressive tumour behaviour. Therefore, we suggest that patients with SCAs, especially patients diagnosed at a young age, require careful long-term monitoring. |
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Authors:
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Hwa Young Cho; Sun Wook Cho; Sang Wan Kim; Chan Soo Shin; Kyong Soo Park; Seong Yeon Kim |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-07-24 |
Journal Detail:
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Title: Clinical endocrinology Volume: 72 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 648-53 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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metabolism,
pathology*,
surgery Adolescent Adrenocorticotropic Hormone / analysis* Adult Age Factors Aged Female Humans Male Middle Aged Neoplasm Recurrence, Local* Pituitary Neoplasms / metabolism, pathology*, surgery Retrospective Studies Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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