Document Detail

Silent cerebral white matter lesions and cognitive function in middle-aged essential hypertensive patients.
MedLine Citation:
PMID:  15177527     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An association between midlife blood pressure levels and late-life cognitive impairment has been reported. Hypertension is one of the most important factors related to the presence of cerebral white matter lesions, which is a prognostic factor for the development of cognitive impairment. Studies have shown a relationship between white matter lesions and cognitive decline in elderly hypertensive patients. The aim of the present study was to evaluate cognitive function in asymptomatic middle-aged hypertensive patients according to the presence or absence of white matter lesions. METHODS: Sixty never-treated essential hypertensive patients (38 men, 22 women), aged 50 to 60 years (mean age, 54.4 +/- 3.8 years), without clinical evidence of target organ damage, were studied. All patients underwent brain magnetic resonance imaging to establish the presence or absence of white matter lesions, using the Rotterdam criteria. Cognitive function was evaluated by a neuropsychologic test battery measuring attention, memory, intelligence, anxiety, and depression. RESULTS: Twenty-three hypertensive patients (38%) were found to have white matter lesions on brain resonance. These patients exhibited a significantly worse performance on digit span forward, a standardized measure of attention than hypertensives without white matter lesions (4.86 +/- 1.14 v 5.51 +/- 0.97; P =.027). Hypertensive patients with white matter lesions showed no differences on both visual and logical memory tests when compared with patients without lesions. CONCLUSIONS: We conclude that the presence of silent cerebral white matter lesions in middle-aged hypertensive patients is associated with a mild decline in basic attention.
Cristina Sierra; Alejandro De La Sierra; Manel Salamero; Javier Sobrino; Elisenda Gómez-Angelats; Antonio Coca
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  17     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-04     Completed Date:  2004-11-06     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-34     Citation Subset:  IM    
Hypertension Unit, Department of Internal Medicine, Hospital Clínic, University of Barcelona, Barcelona, Spain.
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MeSH Terms
Blood Pressure / physiology
Brain / pathology,  radiography
Brain Diseases / physiopathology*,  radiography
Cerebral Ventricles / physiopathology*
Cognition / physiology*
Diastole / physiology
Hypertension / physiopathology*,  radiography
Magnetic Resonance Imaging
Middle Aged
Severity of Illness Index
Statistics as Topic
Systole / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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