Document Detail

Silent cerebral infarction, income and grade retention among students with sickle cell.
MedLine Citation:
PMID:  25042018     Owner:  NLM     Status:  Publisher    
Children with sickle cell anemia have a higher-than-expected prevalence of poor educational attainment. We test two key hypotheses about educational attainment among students with sickle cell anemia, as measured by grade retention and use of special education services: 1) lower household per capita income is associated with lower educational attainment; 2) the presence of a silent cerebral infarct is associated with lower educational attainment. We conducted a multicenter, cross-sectional study of cases from 22 U.S. sites included in the Silent Infarct Transfusion Trial. During screening, parents completed a questionnaire that included sociodemographic information and details of their child's academic status. Of 835 students, 670 were evaluable; 536 had data on all covariates and were used for analysis. The students' mean age was 9.4 years (range, 5 - 15) with 52.2% male; 17.5% of students were retained one grade level and 18.3% received special education services. A multiple variable logistic regression model identified that lower household per capita income (odds ratio [OR] of quartile 1=6.36, OR of quartile 2=4.7, OR of quartile 3=3.87; p=0.001 for linear trend), age (OR=1.3; p<0.001), and male gender (OR, 2.2; p=0.001) were associated with grade retention; silent cerebral infarct (p=0.31) and painful episodes (p=0.60) were not. Among students with sickle cell anemia, household per capita income is associated with grade retention, whereas the presence of a silent cerebral infarct is not. Future educational interventions will need to address both the medical and socioeconomic issues that affect students with sickle cell anemia.
Allison A King; Mark J Rodeghier; Julie Ann Panepinto; John J Strouse; James F Casella; Charles Quinn; Michael Dowling; Sharada A Sarnaik; Alexis A Thompson; Gerald M Woods; Caterina P Minniti; Rupa C Redding-Lallinger; Melanie Kirby-Allen; Fenella J Kirkham; Robert McKinstry; Michael J Noetzel; Desiree A White; Janet K Kwiatkowski; Thomas H Howard; Karen A Kalinyak; Baba Inusa; Melissa M Rhodes; Mark E Heiny; Ben Fuh; Jason M Fixler; Mae O Gordon; Michael R DeBaun
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-15
Journal Detail:
Title:  American journal of hematology     Volume:  -     ISSN:  1096-8652     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc., A Wiley Company.
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