Document Detail


Silent central nervous system involvement in Egyptian Behçet's disease patients: clinical, psychiatric, and neuroimaging evaluation.
MedLine Citation:
PMID:  21384256     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Behçet's disease (BD) is an idiopathic multisystem disorder. Involvement of CNS occurs in 4-48% of cases. This study was designed to evaluate the prevalence of subclinical neuropsychiatric affection in asymptomatic Egyptian BD patients using psychometric tests and brain imaging with single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI), also to assess possibly associated clinical predictive variables. Twenty-five BD patients without overt CNS involvement and ten healthy controls matched for age, education, and sex completed a comprehensive neuropsychological battery including Hamilton scales for anxiety and depression and Wechsler memory scale-revised. Disease activity was assessed using Behçet's Disease Current Activity Form (BDCAF). SPECT was done for all subjects, and 12 patients underwent brain MRI. Compared to controls, 23 (92%) and 24 (96%) patients had anxiety and depression scores respectively above normal range; also, BD patients had significantly lower memory quotient (MQ). SPECT revealed abnormalities in 16/25 (64%), while in 3/12 patients (25%), MRI was abnormal. Subjects with abnormal SPECT had significantly higher ages than those with normal SPECT (P = 0.02) and were more frequently males (P = 0.03). No statistically significant differences between cases with normal or abnormal SPECT were found regarding disease duration, frequency of headache, BDCAF, frequency of active eye disease, major vascular involvement, mean Hamilton anxiety and depression scores, and mean MQ. Early diagnosis of neurological involvement in BD is important in reducing or preventing complications. Neuropsychiatric evaluation and HMPAO brain SPECT were found to be useful for detecting subclinical neurological abnormalities in BD patients.
Authors:
Hania Zayed; Dina Effat; Zeinab Nawito; Amany Ahmed Abdou; Mohamed Nasr El Din; Sherif El-Refaei; Mahasen Amin; Yasser Mohamed; Amr Amin; Ahmed Wafie; Khaled Abu El-Einin
Related Documents :
9588266 - Ankylosing spondylitis in singapore: a study of 150 patients and a local update.
821096 - Evaluation of scintigraphic and roentgenologic studies in paget's disease under treatment.
15030456 - Oral versus intravenous ganciclovir for the prophylaxis of cytomegalovirus disease afte...
2048566 - Clinical effects of recombinant human interleukin-3.
24252016 - Study on the safety and efficacy of tocilizumab, an anti-il-6 receptor antibody, in pat...
9832096 - Use of sublingual nitroglycerin during head-up tilt-table testing in patients >60 years...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-8
Journal Detail:
Title:  Clinical rheumatology     Volume:  -     ISSN:  1434-9949     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Rheumatology & Rehabilitation, Faculty of Medicine, Cairo University, Giza, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Wasabi nose: an underreported complication of cyclophosphamide infusions.
Next Document:  Efficacy and safety of repeat courses of rituximab treatment in patients with severe refractory juve...