| Silent Pulmonary Embolism in Patients with Proximal Deep Vein Thrombosis in the Lower Limbs. | |
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MedLine Citation:
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PMID: 22288520 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: One in every three patients with deep vein thrombosis (DVT) in the lower limbs may have silent pulmonary embolism (PE), but its clinical relevance has not been thoroughly studied. Methods: We used the RIETE Registry data to study patients with proximal DVT and no PE symptoms, but with a systematic search for PE. We compared the outcome of DVT patients with silent PE and those with no PE. Results: Of 2375 patients with DVT, 842 (35%) had silent PE and 1533 had no PE. During the first 15 days of anticoagulation, patients presenting with silent PE had a higher incidence of symptomatic PE events than those with no PE (0.95% vs. 0.13%; p=0.015), with a similar incidence of major bleeding (0.95% vs. 1.63%; p=0.09). In patients with silent PE, the incidence of PE events during the first 15 days was equal to the incidence of major bleeding (8 events each), but in those with no PE the incidence of PE events was 8 times lower (3 vs. 25 bleeding events). Multivariate analysis confirmed that DVT patients with silent PE had a higher incidence of symptomatic PE events during the first 15 days than those with no PE (odds ratio: 4.80; 95% CI: 1.27-18.1), with no differences in bleeding. Conclusions: DVT patients with silent PE at baseline had an increased incidence of symptomatic PE events during the first 15 days of anticoagulant therapy. This effect disappeared after 3 months of anticoagulation. |
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Authors:
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I Tzoran; G Saharov; B Brenner; D Delsart; P Román; A Visoná; D Jiménez; M Monreal; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: - ISSN: 1538-7836 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 International Society on Thrombosis and Haemostasis. |
Affiliation:
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Thrombosis & Hemostasis Unit; Rambam-Health Care Campus Haifa, Israel Inserm, CIE3, F-42055 Saint-Etienne, France; Univ Saint-Etienne, EA3065, Saint-Etienne, F-42023 CHU Saint-Etienne, Hôpital Nord. Department of Medicine and Therapeutic, Saint-Etienne, F-42055, France Department of Internal Medicine. Hospital General de Requena. Valencia. Spain Angiology Unit. San Giacomo Hospital. Castelfranco Veneto (TV), Italy Respiratory Department. Hospital Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS. Madrid Department of Internal Medicine. Hospital Universitari Germans Trias i Pujol. Badalona, Barcelona. Spain. |
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