| Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D1 cells. | |
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MedLine Citation:
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PMID: 19125248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member glycoprotein enriched on the surface of many malignant tumor cells, promotes tumor progression and confers resistance to some chemotherapeutic drugs. To investigate the possible role of CD147 in the macrophage-like lymphoid neoplasm P388D1 cells progression, we used RNA interference approach to silence CD147 expression. The results showed that silencing of CD147 in P388D1 cells impeded the expression of MMP11 at both mRNA and protein levels. The reduced CD147 expression also resulted in reductions in tumorigenicity, as well as decreased in regional lymph node metastasis. Furthermore, the down-regulation of CD147 expression sensitized cells to be more sensitive to chemotherapeutic drugs. Treatment of tumor cells with U-0126, an inhibitor of mitogen-activated protein kinase/Erk, also down-regulated the expression of MMP11. Our current results indicate that the expression of CD147 functionally mediates tumor progression and is a potential target for therapeutic anti-cancer drugs. |
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Authors:
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Li Jia; Wei Wei; Jun Cao; Henggui Xu; Xiaoyan Miao; Jianing Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-01 |
Journal Detail:
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Title: Annals of hematology Volume: 88 ISSN: 1432-0584 ISO Abbreviation: Ann. Hematol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-06-17 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 753-60 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian, Liaoning Province, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD147 / genetics*, physiology Antineoplastic Agents / pharmacology Cell Line, Tumor Disease Progression Drug Resistance, Neoplasm / drug effects* Gene Silencing* Lymph Nodes / pathology Lymphoma / drug therapy*, pathology Matrix Metalloproteinase 11 / antagonists & inhibitors Mice Mice, Inbred DBA Neoplasm Metastasis / drug therapy Neoplasm Transplantation RNA, Small Interfering / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Bsg protein, mouse; 0/RNA, Small Interfering; 136894-56-9/Antigens, CD147; EC 3.4.24.-/Matrix Metalloproteinase 11 |
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