Document Detail


"Silenced" polydendrocytes: a new cell type within the oligodendrocyte progenitor cell population?
MedLine Citation:
PMID:  20217137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oligodendrocyte progenitor cells (OPCs) were first described more than two decades ago. Novel labeling techniques have shown them to be cells with more than just progenitor functions, with their classification as a fourth glial cell type in addition to astrocytes, oligodendrocytes, and microglial cells. Another term used for this cell type is polydendrocytes, owing to both their morphology and to the evolving knowledge about their diverse functions. Recently, an exclusive hallmark of neurons--the generation of action potentials--became debatable, because a subset of polydendrocytes was reported to generate action potentials in response to adequate stimuli. The new technique of inducible reporter gene expression has brought new insights into the fate and function of polydendrocytes. In recent studies, so-called "silenced" OPCs were detected in cortical tissue, and which underwent proliferation with subsequent cell cycle exit, but without any signs of differentiation. Within this review, we focus on the identification of this new subset of polydendrocytes and their possible functions within cortical networks.
Authors:
Andreas Hermann; Moritz D Brandt; Kai F Loewenbr?ck; Alexander Storch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-09
Journal Detail:
Title:  Cell and tissue research     Volume:  340     ISSN:  1432-0878     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
Affiliation:
Department of Neurology and Center for Regenerative Therapies Dresden, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany. andreas.hermann@uniklinikum-dresden.de
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Antigens / metabolism
Biological Markers / metabolism
Cell Communication / physiology
Cerebral Cortex / cytology*,  physiology*
Genes, Reporter / physiology
Molecular Biology / methods
Nerve Growth Factors / metabolism,  secretion
Oligodendroglia / cytology*,  physiology*
Proteoglycans / metabolism
Stem Cells / cytology*,  physiology*
Synaptic Transmission / physiology
Chemical
Reg. No./Substance:
0/Antigens; 0/Biological Markers; 0/Nerve Growth Factors; 0/Proteoglycans; 0/chondroitin sulfate proteoglycan 4

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