Document Detail


Silence from within: endogenous siRNAs and miRNAs.
MedLine Citation:
PMID:  16009127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although eukaryotic cells use RNA silencing to defend against transposons and pathogens, they also employ these pathways to regulate the expression of their own genes. Recent results have uncovered new examples of RNA silencing in controlling endogenous gene expression and have revealed novel mechanisms of downregulation. Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands.
Authors:
Erik J Sontheimer; Richard W Carthew
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell     Volume:  122     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-12     Completed Date:  2005-08-22     Revised Date:  2013-06-20    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208, USA. erik@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Eukaryotic Cells / cytology,  metabolism
Gene Silencing*
Humans
MicroRNAs / genetics*
RNA, Small Interfering / genetics*
Grant Support
ID/Acronym/Agency:
R01 GM068743/GM/NIGMS NIH HHS; R01 GM077581/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Small Interfering

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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