| Sildenafil-nitric oxide donor combination promotes ventricular tachyarrhythmias in the swine right ventricle. | |
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MedLine Citation:
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PMID: 11959644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We tested the hypothesis that sildenafil, singly or in combination with nitric oxide (NO) donors, promotes ventricular tachycardia (VT) and ventricular fibrillation (VF). Vulnerability to VT/VF was tested by rapid pacing in eight isolated normal swine right ventricles (RV). The endocardial activation was optically mapped, and the dynamic action potential duration (APD) restitution curves were constructed with metal microelectrodes. At baseline, no VT/VF could be induced. Sildenafil (0.2 microg/ml) or NO donor singly or in combination did not alter VT/VF vulnerability. However, when 2 microg/ml sildenafil was combined with NO donors, the incidence of VT and VF rose significantly (P < 0.01). VT with a single periodic wavefront was induced in five of eight RVs, and VF with multiple wavefronts was induced in all eight RVs. The sildenafil-NO donor pro-VT/VF combination significantly increased the maximum slope of the APD restitution curve and the amplitude of the APD alternans. The pro-VT/VF effects of sildenafil were reversible after drug-free Tyrode solution perfusion. We conclude that a sildenafil (2 microg/ml) and NO donor combination increases VT/VF vulnerability in the normal RV by a mechanism compatible with the restitution hypothesis. |
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Authors:
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Moshe Swissa; Toshihiko Ohara; Moon-Hyoung Lee; Sanjay Kaul; Prediman K Shah; Hideki Hayashi; Peng-Sheng Chen; Hrayr S Karagueuzian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 282 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-04-17 Completed Date: 2002-05-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1787-92 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles 90048, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Female Male Nitric Oxide Donors / administration & dosage*, adverse effects* Piperazines / administration & dosage*, adverse effects* Purines Sulfones Swine Tachycardia, Ventricular / chemically induced* Ventricular Dysfunction, Right / chemically induced* Ventricular Fibrillation / chemically induced |
| Grant Support | |
ID/Acronym/Agency:
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HL-52319/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitric Oxide Donors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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