Document Detail


Sildenafil: emerging cardiovascular indications.
MedLine Citation:
PMID:  15464535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery in 1989 of sildenafil, a highly selective inhibitor of phosphodiesterase-5 (PDE-5), was the result of extensive research on chemical agents targeting PDE-5 that might potentially be useful in the treatment of coronary heart disease. Initial clinical studies on sildenafil in the early 1990s were not promising with respect to its antianginal potential. However, the incidental discovery of its antiimpotence effect led to its approval of for the treatment of erectile dysfunction. Thereafter, several reports of adverse cardiac events in patients on sildenafil raised concerns about its safety in cardiovascular disorders. Novel therapeutic indications are emerging for sildenafil with the recent discovery that PDE-5 is expressed in various other tissues such as the arterial vasculature, including pulmonary and coronary arteries, venous vasculature, skeletal muscles, platelets, and visceral and tracheobronchial muscles. In this review we briefly summarize the pharmacology of sildenafil and the current available evidence on its potential therapeutic applications in cardiovascular disorders.
Authors:
Shahzad G Raja; Suneela H Nayak
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  78     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2005-06-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1496-506     Citation Subset:  AIM; IM    
Affiliation:
Department of Paediatric Cardiac Surgery, Alder Hey Children's Hospital, West Derby, Liverpool, United Kingdom. drrajashahzad@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
3',5'-Cyclic-GMP Phosphodiesterases
Aged
Blood Platelets / drug effects
Cardiovascular Diseases / drug therapy*
Child
Coronary Circulation / drug effects
Cyclic Nucleotide Phosphodiesterases, Type 5
Endothelium, Vascular / drug effects,  physiopathology
Female
Hemodynamics / drug effects
Humans
Hypertension, Pulmonary / drug therapy
Male
Middle Aged
Myocardial Contraction / drug effects
Phosphodiesterase Inhibitors / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Phosphoric Diester Hydrolases / classification,  drug effects,  physiology
Piperazines / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Pulmonary Circulation / drug effects
Purines
Stress, Physiological / physiopathology
Sulfones
Sympathetic Nervous System / drug effects
Vasodilator Agents / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil; EC 3.1.4.-/Phosphoric Diester Hydrolases; EC 3.1.4.35/3',5'-Cyclic-GMP Phosphodiesterases; EC 3.1.4.35/Cyclic Nucleotide Phosphodiesterases, Type 5; EC 3.1.4.35/PDE5A protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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