Document Detail

Sildenafil and a compound stimulating endothelial NO synthase modify sexual incentive motivation and copulatory behavior in male Wistar and Fisher 344 rats.
MedLine Citation:
PMID:  18637997     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Earlier studies have shown that sildenafil may modify some aspects of male rat sexual behavior and sexual incentive motivation. Stimulation of endothelial nitric oxide synthase (eNOS) has also been reported to affect sexual motivation in old rats. AIM: To determine the effects of sildenafil and a compound stimulating eNOS on copulatory behavior and sexual incentive motivation in young adult Fisher 344 and Wistar male rats. METHODS: The rats were selected for a low intromission ratio, and then treated with Impaza (stimulator of eNOS), sildenafil, or Impaza + sildenafil for 28 days. Tests for copulatory behavior and sexual incentive motivation were performed before the beginning of treatment and at days 7, 14, and 28 of treatment. MAIN OUTCOME MEASURES: Standard parameters of copulatory behavior and sexual incentive motivation. Measurements of penis length at mount, intromission, and ejaculation. RESULTS: The Fisher 344 rats displayed a higher level of sexual incentive motivation than the Wistar rats, while the copulatory behavior was similar in both strains. Impaza and sildenafil enhanced the sexual incentive motivation after 28 days of treatment in the Wistar rats, but failed to do so in the Fisher 344 rats. The copulatory behavior was unaffected in the Wistar strain, while the Fisher 344 males had an enhanced intromission ratio after treatment with Impaza and sildenafil for 28 days. CONCLUSIONS: The nitric oxide-guanylyl cyclase pathway seems to be of importance for sexual incentive motivation in animals with a modest baseline level. The different drug effects in the Wistar and Fisher 344 rats can be attributed to baseline differences. The importance of eNOS for sexual functions should not be overlooked.
Xi Chu; Ekaterina S Zhavbert; Julia L Dugina; Irina A Kheyfets; Svetlana A Sergeeva; Oleg I Epstein; Anders Agmo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-15
Journal Detail:
Title:  The journal of sexual medicine     Volume:  5     ISSN:  1743-6109     ISO Abbreviation:  -     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-11     Completed Date:  2009-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230693     Medline TA:  J Sex Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2085-99     Citation Subset:  IM    
Department of Medical Physiology, University of Tromsø, Tromsø, Norway.
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MeSH Terms
Administration, Oral
Antibodies / pharmacology*
Copulation / drug effects*
Cyclic Nucleotide Phosphodiesterases, Type 5 / antagonists & inhibitors
Libido / drug effects*,  physiology
Nitric Oxide Synthase Type III / physiology*
Penile Erection / drug effects
Phosphodiesterase Inhibitors / pharmacology*
Piperazines / pharmacology*
Purines / pharmacology
Rats, Inbred F344
Rats, Wistar
Sexual Behavior, Animal / drug effects*,  physiology
Species Specificity
Sulfones / pharmacology*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Antibodies; 0/IMPAZA; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil; EC Oxide Synthase Type III; EC Nucleotide Phosphodiesterases, Type 5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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