Document Detail

Sildenafil as a pulmonary vasodilator after repair of congenital heart disease.
MedLine Citation:
PMID:  18306725     Owner:  NLM     Status:  MEDLINE    
We describe successful use of enteral sildenafil following surgery for congenital heart disease in three cases. One infant after repair of ventricular septal defect and aortic coarctation had pulmonary hypertension non-responsive to nitric oxide, another infant and 3.5 year child following palliative surgery for congenital heart disease with univentricular physiology were treated with inhaled nitric oxide and had severe systemic desaturations associated with endotracheal suctioning. Therapy with sildenafil reduced pulmonary arterial pressure, prevented episodes of arterial desaturations and allowed weaning from nitric oxide (Ref. 7). Full Text (Free, PDF)
L Kovacikova; M Zahorec; M Nosal
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  108     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2007  
Date Detail:
Created Date:  2008-02-29     Completed Date:  2008-04-22     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  453-4     Citation Subset:  IM    
Intensive Care Unit, Pediatric Cardiac Center, Bratislava, Slovakia.
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MeSH Terms
Heart Defects, Congenital / surgery*
Hypertension, Pulmonary / drug therapy*,  etiology,  physiopathology
Phosphodiesterase Inhibitors / therapeutic use*
Piperazines / therapeutic use*
Postoperative Complications*
Purines / therapeutic use
Sulfones / therapeutic use*
Vascular Resistance
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

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