Document Detail


Sildenafil (Viagra) reduces arrhythmia severity during ischaemia 24 h after oral administration in dogs.
MedLine Citation:
PMID:  14744808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sildenafil (Viagra) prolongs repolarisation in cardiac muscle, an effect that could lead to ventricular fibrillation (VF). Sildenafil (2 mg kg(-1)) was given by mouth to 12 mongrel dogs and, 24 h later, these dogs were anaesthetised, thoracotomised and subjected to a 25 min occlusion of the anterior descending coronary artery. Haemodynamic parameters were similar in this and the control group, but there were fewer and less serious ventricular arrhythmias during occlusion in the sildenafil group (VF 17 vs 60%; ventricular premature beats 140+/-52 vs 437+/-127% and episodes of ventricular tachycardia 4.0+/-3.2 vs 19.3+/-7.7%, all P<0.05). However, reperfusion VF and indices of ischaemia severity (epicardial ST-segment mapping, inhomogeneity) were not modified by the drug. Sildenafil increased the QT interval, especially during ischaemia. Our conclusion is that ischaemia-induced ventricular arrhythmias are reduced by sildenafil, but this protection is less pronounced than that following cardiac pacing or exercise.
Authors:
Orsolya Nagy; Agnes Hajnal; James R Parratt; Agnes Végh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-26
Journal Detail:
Title:  British journal of pharmacology     Volume:  141     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-20     Completed Date:  2004-10-14     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  549-51     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Pharmacotherapy, University of Szeged, Albert Szent-Györgyi Faculty of Medicine, Dóm tér 12, PO Box 427, H-6701 Hungary.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents*
Arrhythmias, Cardiac / etiology,  prevention & control*
Coronary Vessels / physiology
Dogs
Electrocardiography
Hemodynamics / drug effects,  physiology
Myocardial Reperfusion Injury / complications*
Phosphodiesterase Inhibitors / pharmacology*
Piperazines / pharmacology*
Purines
Stroke Volume / drug effects
Sulfones
Tachycardia, Ventricular / physiopathology,  prevention & control
Ventricular Dysfunction, Left / physiopathology,  prevention & control
Ventricular Fibrillation / physiopathology,  prevention & control
Ventricular Premature Complexes / physiopathology,  prevention & control
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 3M7OB98Y7H/sildenafil
Comments/Corrections

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