Document Detail


Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restriction.
MedLine Citation:
PMID:  20018809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adequate placental blood flow is essential for the optimal delivery of nutrients from mother to fetus for conceptus growth. Restricted fetal development results from pathophysiological and environmental factors that alter utero-placental blood flow, placental function, and, therefore, nutrient availability in the fetus. To test this hypothesis, 0, 75, or 150 mg/d sildenafil citrate (Viagra) was administered subcutaneously from d 28 to 115 of gestation to either nutrient-restricted [50% of NRC requirements) or adequately-fed ewes (100% of NRC requirements). On d 115, maternal, fetal, and placental tissues and fluids were collected. Concentrations of total amino acids and polyamines in uterine venous and arterial sera, amniotic and allantoic fluids, and fetal umbilical venous serum were lower (P < 0.05) in nutrient-restricted ewes than in adequately fed ewes, as were the ratios of total amino acids in fetal umbilical venous serum to uterine arterial serum. Sildenafil citrate dose-dependently increased (P < 0.05) total amino acids and polyamines in amniotic fluid, allantoic fluid, and fetal serum without affecting values in maternal serum. Fetal weight was lower (P < 0.05) in nutrient-restricted ewes on d 115. Sildenafil citrate treatment dose-dependently increased (P < 0.05) fetal weight in both nutrient-restricted and adequately fed ewes. This study supports the hypothesis that long-term sildenafil citrate treatment enhances fetal growth, at least in part, by increasing the availability of amino acids in the conceptus. These findings may lead to the clinical use of sildenafil citrate in human pregnancies suspected to be at risk for intrauterine fetal growth retardation.
Authors:
M Carey Satterfield; Fuller W Bazer; Thomas E Spencer; Guoyao Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-16
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-8     Citation Subset:  IM    
Affiliation:
Department of Animal Science, Texas A&M University, College Station, TX 77843-2471, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood*
Amniotic Fluid / metabolism
Animal Nutritional Physiological Phenomena / drug effects
Animals
Dietary Proteins / blood
Disease Models, Animal
Dose-Response Relationship, Drug
Embryonic Development / drug effects
Female
Fetal Growth Retardation / blood,  prevention & control*
Fetal Weight / drug effects*
Fetus / blood supply,  drug effects*,  metabolism
Maternal Nutritional Physiological Phenomena
Piperazines / administration & dosage,  pharmacology,  therapeutic use*
Placenta / blood supply,  drug effects
Polyamines / blood
Pregnancy
Prenatal Nutritional Physiological Phenomena / drug effects*
Purines / administration & dosage,  pharmacology,  therapeutic use
Sheep
Sulfones / administration & dosage,  pharmacology,  therapeutic use*
Umbilical Veins / metabolism
Uterine Artery / metabolism
Vasodilator Agents / administration & dosage,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Dietary Proteins; 0/Piperazines; 0/Polyamines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

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