| Sildenafil Citrate Rescues Fetal Growth in the Catechol-O-Methyl Transferase Knockout Mouse Model. | |
| | |
MedLine Citation:
|
PMID: 22392899 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preeclampsia. The ability of sildenafil citrate to increase uterine artery vasodilation, thereby decreasing uterine artery resistance and, hence, ameliorated preeclampsia and fetal growth restriction, was tested in a mouse model of preeclampsia, the catechol-O-methyl transferase knockout mouse (COMT(-/-)). COMT(-/-) and C57BL/6J mice were treated (0.2 mg/mL in drinking water, n=6-12) from gestational day 12.5 to 18.5. Measures of pup growth, including body weight, crown/rump length, and abdominal circumference, were reduced in COMT(-/-) mice; this was normalized after treatment with Sildenafil. COMT(-/-) mice also demonstrated abnormal umbilical Doppler waveforms, including reverse arterial blood flow velocity. This was normalized after treatment with Sildenafil. Abnormal uterine artery Doppler waveforms were not demonstrated in COMT(-/-) mice, although ex vivo responses of uterine arteries to phenylephrine were increased; moreover, treatment with Sildenafil did improve ex vivo sensitivity to an endothelium-dependent vasodilator. The data presented here demonstrate that Sildenafil can rescue pup growth and improve abnormal umbilical Doppler waveforms, providing support for a potential new therapeutic strategy targeting fetal growth restriction. |
| | |
Authors:
|
Joanna L Stanley; Irene J Andersson; Rajan Poudel; Christian F Rueda-Clausen; Colin P Sibley; Sandra T Davidge; Philip N Baker |
Related Documents
:
|
6688439 - Actinobacillus actinomycetemcomitans endocarditis in hypertrophic obstructive cardiomyo... 3140859 - Familial neurofibromatosis and hypertrophic cardiomyopathy. 15682049 - The impaired flow reserve capacity of penetrating intramyocardial coronary arteries in ... 21224779 - Left main minimal plaque burden complicated by an acute massive thrombosis: diagnostic ... 7724139 - Aorto-pulmonary calcification: an unusual manifestation of idiopathic calcification of ... 19777369 - Obstruction and sequestration: a case of apical hypertrophic cardiomyopathy concomitant... 10655929 - Living related donor liver transplantation in a patient with severe aortic stenosis. 19012219 - Neonatal kawashima intraventricular repair for taussig-bing anomaly with oblique relati... 8371309 - Traumatic mitral valve rupture during the hillsborough football disaster: case report. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-3-5 |
Journal Detail:
|
Title: Hypertension Volume: - ISSN: 1524-4563 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-3-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Obstetrics and Gynecology and Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada; Maternal and Fetal Health Research Centre, University of Manchester, Manchester, United Kingdom; Women's and Children's Health Research Institute, Edmonton, Alberta, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analogues of the frog skin peptide alyteserin-2a with enhanced antimicrobial activities against Gram...
Next Document: The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 re...