Document Detail

Significantly higher plasma haloperidol level during cotreatment with carbamazepine may herald cardiac change.
MedLine Citation:
PMID:  8726546     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of carbamazepine (CBZ) cotreatment with haloperidol (HP) on cardiac change in Japanese psychiatric patients without heart disease. Of 21 patients cotreated with CBZ, 11 showed lengthening of QT interval corrected for heart rate (QTc) (> 440, mean percentage change, 29), of whom two patients developed congestive heart failure because of left ventricular dysfunction. Especially in these two patients, plasma HP levels were significantly higher than speculated from the correlations. It is possible to speculate that, especially on CBZ cotreatment, significantly higher HP plasma level with QTc prolongation may herald heart failure.
K Iwahashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  19     ISSN:  0362-5664     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-70     Citation Subset:  IM    
Department of Neuropsychiatry, Kagawa Medical School, Japan.
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MeSH Terms
Anticonvulsants / administration & dosage,  adverse effects*
Antipsychotic Agents / administration & dosage,  adverse effects*,  blood
Carbamazepine / administration & dosage,  adverse effects*
Drug Therapy, Combination
Haloperidol / administration & dosage,  adverse effects*,  blood
Heart Failure / chemically induced
Long QT Syndrome / chemically induced*
Middle Aged
Schizophrenia / drug therapy*
Ventricular Dysfunction, Left / chemically induced
Reg. No./Substance:
0/Anticonvulsants; 0/Antipsychotic Agents; 298-46-4/Carbamazepine; 52-86-8/Haloperidol
Comment In:
Clin Neuropharmacol. 1997 Apr;20(2):179   [PMID:  9099473 ]

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