Document Detail

Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1.
MedLine Citation:
PMID:  21846428     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.
Sunghee Lee; J David Curb; Takashi Kadowaki; Rhobert W Evans; Katsuyuki Miura; Tomoko Takamiya; Chol Shin; Aiman El-Saed; Jina Choo; Akira Fujiyoshi; Teruo Otake; Sayaka Kadowaki; Todd Seto; Kamal Masaki; Daniel Edmundowicz; Hirotsugu Ueshima; Lewis H Kuller; Akira Sekikawa
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-08-16
Journal Detail:
Title:  The British journal of nutrition     Volume:  107     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-03-21     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  567-72     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid / blood
Asian Americans
Asian Continental Ancestry Group
Body Mass Index
Cohort Studies
Coronary Disease / blood,  epidemiology*,  ethnology
Cross-Sectional Studies
European Continental Ancestry Group
Fatty Acids, Omega-6 / administration & dosage,  blood*
Hawaii / epidemiology
Japan / epidemiology,  ethnology
Linoleic Acid / blood
Middle Aged
Models, Biological
Pennsylvania / epidemiology
Plasminogen Activator Inhibitor 1 / blood*
Risk Factors
Grant Support
HL071561/HL/NHLBI NIH HHS; R01 HL068200/HL/NHLBI NIH HHS; R01 HL068200-01A1/HL/NHLBI NIH HHS; R01 HL068200-02/HL/NHLBI NIH HHS; R01 HL068200-03/HL/NHLBI NIH HHS; R01 HL068200-04/HL/NHLBI NIH HHS; R01 HL068200-05/HL/NHLBI NIH HHS; R01 HL068200-06/HL/NHLBI NIH HHS; R01 HL068200-07/HL/NHLBI NIH HHS; R01 HL68200/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Fatty Acids, Omega-6; 0/Plasminogen Activator Inhibitor 1; 0/SERPINE1 protein, human; 27YG812J1I/Arachidonic Acid; 9KJL21T0QJ/Linoleic Acid

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