| Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. | |
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MedLine Citation:
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PMID: 21846428 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1. |
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Authors:
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Sunghee Lee; J David Curb; Takashi Kadowaki; Rhobert W Evans; Katsuyuki Miura; Tomoko Takamiya; Chol Shin; Aiman El-Saed; Jina Choo; Akira Fujiyoshi; Teruo Otake; Sayaka Kadowaki; Todd Seto; Kamal Masaki; Daniel Edmundowicz; Hirotsugu Ueshima; Lewis H Kuller; Akira Sekikawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-16 |
Journal Detail:
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Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
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Languages: ENG Pagination: 1-6 Citation Subset: - |
Affiliation:
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Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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