Document Detail


Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation.
MedLine Citation:
PMID:  16889615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genetic events that lead to tumour progression in plasma cell dyscrasia are not well understood. Interphase cytoplasmic fluorescence in situ hybridisation was used to investigate the CKS1B amplification status (at 1q21) in clonal plasma cells from 123 patients: 23 monoclonal gammopathy of undetermined significance (MGUS), 75 multiple myeloma (MM) and 26 plasma cell leukaemia (PCL). While CKS1B amplification was absent in MGUS patients, such amplification (3-8 copies) was detected in 36% of newly diagnosed MM, 52% relapsed MM and 62% PCL (P < 0.001). Our results suggest that CKS1B amplification is associated with transformation from MGUS to MM and progression to PCL.
Authors:
Hong Chang; Joanna Yeung; Wei Xu; Yi Ning; Bruce Patterson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-01
Journal Detail:
Title:  British journal of haematology     Volume:  134     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-29     Completed Date:  2006-11-06     Revised Date:  2012-06-19    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  613-5     Citation Subset:  IM    
Affiliation:
Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, ON, Canada. hong.chang@uhn.on.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carrier Proteins / genetics*
Chi-Square Distribution
Cyclin-Dependent Kinases / genetics*
Disease Progression
Female
Gene Amplification*
Humans
In Situ Hybridization, Fluorescence
Interphase
Leukemia, Plasma Cell / genetics*
Male
Middle Aged
Monoclonal Gammopathy of Undetermined Significance / genetics*
Multiple Myeloma / genetics*
Chemical
Reg. No./Substance:
0/CKS1B protein, human; 0/Carrier Proteins; EC 2.7.11.22/Cyclin-Dependent Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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