Document Detail

Significant improvement in arterial stiffness after endurance training in patients with COPD.
MedLine Citation:
PMID:  19880908     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Arterial stiffness, a strong predictor of cardiovascular mortality, is abnormally elevated in patients with COPD. We investigated whether exercise training may decrease arterial stiffness in patients with COPD. METHODS: Seventeen stable patients with COPD were included in this case-controlled study. Trained (n = 10) and untrained (n = 7) patients were matched for age (62 +/- 7 years), disease severity (FEV(1) = 50% +/- 17% predicted) and walking distance (412 +/- 70 m). Carotid-radial pulse wave velocity (PWV, a measure of arterial stiffness), pulmonary function, BP, plasmatic biomarkers, walking distance, and peripheral muscle function were evaluated in the two groups at baseline and after 4 weeks. In trained patients, aerobic capacity was also assessed during incremental exercise on a cycloergometer, before and after training. RESULTS: Baseline PWV was similar between both groups. PWV was stable after 4 weeks in untrained patients with COPD, whereas it was reduced in trained patients (from 10.3 +/- 0.7 to 9.2 +/- 0.8 m/s, P = .001). PWV reduction correlated with improvements in walking distance (r = -0.49), muscle endurance (r = -0.48), systolic BP (r = 0.79), and fasting glucose (r = 0.59) in all patients (P < .05), and with changes in maximal heart rate and oxygen consumption (r = -0.70, P = .02) in trained patients. CONCLUSIONS: Arterial stiffness appears to improve after exercise training in patients with COPD proportionally to changes in exercise capacity. Suggested mechanisms for arterial stiffness improvement are training-induced reductions in systolic BP and fasting glucose. TRIAL REGISTRATION:; Identifier: NCT00404430.
Isabelle Vivodtzev; Cl?mence Minet; Bernard Wuyam; Jean-Christian Borel; Gabrielle Vottero; Denis Monneret; Jean-Philippe Baguet; Patrick L?vy; Jean-Louis P?pin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-31
Journal Detail:
Title:  Chest     Volume:  137     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  585-92     Citation Subset:  AIM; IM    
INSERM ERI17, Labotatoire HP2 (Hypoxie: Physiopathologie), Grenoble, France.
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MeSH Terms
Brachial Artery / physiopathology*,  ultrasonography
Cardiovascular Diseases / etiology,  physiopathology,  prevention & control*
Carotid Artery, Common / physiopathology*,  ultrasonography
Exercise Therapy / methods*
Follow-Up Studies
Middle Aged
Patient Education as Topic / methods*
Prospective Studies
Pulmonary Disease, Chronic Obstructive / complications,  physiopathology,  rehabilitation*
Risk Factors
Vascular Resistance / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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