Document Detail

Significant improvement of atrophy after eradication therapy in atrophic body gastritis.
MedLine Citation:
PMID:  9793959     Owner:  NLM     Status:  MEDLINE    
Chronic atrophic body gastritis may be induced by H. pylori. Results on the effect of H. pylori eradication therapy have been conflicting. Here, we report on the effect of eradication therapy on both body atrophy and inflammation in 7 patients. They presented with severe or moderate atrophy of the oxyntic mucosa and positive H. pylori histology (Warthin-Starry) and/or serology. Eradication was performed with a standard double or triple therapy regimen. At least 6 weeks after successful eradication therapy, patients underwent rebiopsy and histopathological evaluation of the gastric body. In all 7 patients, the grade of body gastritis improved significantly. Among the patients with severe atrophy before H. pylori eradication, 2 had normal mucosa, 3 low-grade atrophy, and one moderate atrophy after treatment. The one case with moderate atrophy before treatment had normal mucosa after H. pylori eradication. In addition, inflammatory infiltration of the mucosa cleared up in 6 cases and improved from severe to mild in one case after treatment. From these results, we conclude that in patients with histologically demonstrated H. pylori and/or positive H. pylori serology atrophic body mucosa can recover after successful eradication therapy.
G Oberhuber; T Wuendisch; S Rappel; M Stolte
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  194     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-07     Completed Date:  1999-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  609-13     Citation Subset:  IM    
Institute of Clinical Pathology, AKH, University of Vienna, Austria.
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MeSH Terms
Gastric Mucosa / microbiology
Gastritis, Atrophic / diagnosis,  microbiology,  therapy*
Helicobacter Infections / diagnosis,  therapy*
Helicobacter pylori / isolation & purification*
Middle Aged
Serologic Tests
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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