| Significant co-expression of WT1 and MDR1 genes in acute myeloid leukemia patients at diagnosis. | |
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MedLine Citation:
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PMID: 14962262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A high expression of Wilms' tumor gene (WT1) in acute myeloid leukemia (AML) seems to correlate with a poor outcome and its increased levels can be predictive of an impending relapse. WT1 has been shown in vitro to interact with the promoter of the MDR1, a gene involved in the multidrug resistance phenomenon. The aim of this study was to measure, by real-time polymerase chain reaction, levels of WT1 and MDR1 expression, in order to find a possible association between these genes, in a series of 50 newly diagnosed AML cases. Twenty-five percent of patients carried very high (>75 degrees percentile) MDR1- and 23.3%WT1-mRNA levels. Interestingly, high levels of WT1 were significantly correlated with correspondent high levels of MDR1 gene. Nevertheless, the co-expression of these genes did not significantly influence the complete response rate to the induction therapy. Reported data confirm the existence of a co-expression of WT1 and MDR1 genes even in vivo; this may be relevant because one consequence could be the positive selection by chemotherapeutic regimens of cells with higher MDR1 levels already present before treatment. Thus, the association between these genes could suggest avoiding the use of drugs involved in the multidrug resistance (MDR) phenomenon in patients carrying high levels of WT1 at diagnosis. |
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Authors:
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S Galimberti; F Guerrini; G Carulli; R Fazzi; G A Palumbo; F Morabito; M Petrini |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of haematology Volume: 72 ISSN: 0902-4441 ISO Abbreviation: Eur. J. Haematol. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-02-13 Completed Date: 2004-03-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703985 Medline TA: Eur J Haematol Country: Denmark |
Other Details:
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Languages: eng Pagination: 45-51 Citation Subset: IM |
Affiliation:
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Department of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Base Sequence Bone Marrow Cells / pathology DNA Primers Female Gene Expression Regulation, Neoplastic / genetics* Genes, MDR / genetics* Genes, Wilms Tumor* Humans Kidney Neoplasms / genetics Leukemia, Myeloid, Acute / diagnosis, genetics*, pathology Male Middle Aged Polymerase Chain Reaction Predictive Value of Tests Prognosis RNA, Messenger / genetics Retrospective Studies Treatment Outcome WT1 Proteins / genetics* Wilms Tumor / genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/RNA, Messenger; 0/WT1 Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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