Document Detail

Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo).
MedLine Citation:
PMID:  18804790     Owner:  NLM     Status:  MEDLINE    
Radiation-induced (RI) peripheral neuropathy is a rare and severe delayed complication of radiotherapy that is spontaneously irreversible, with no standard of treatment. We previously developed a successful antioxidant treatment in RI fibrosis and necrosis. Two patients with progressive worsening RI lumbosacral polyradiculopathy experienced over several years a significant clinical improvement in their neurological sensorimotor symptoms with long-term pentoxifylline-tocopherol-clodronate treatment, and good safety.
Sylvie Delanian; Jean-Louis Lefaix; Thierry Maisonobe; François Salachas; Pierre-François Pradat
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-09-19
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  275     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  164-6     Citation Subset:  IM    
Oncologie-Radiothérapie, Hôpital Saint-Louis/ APHP, Paris, France.
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MeSH Terms
Antioxidants / therapeutic use*
Clodronic Acid / therapeutic use*
Drug Therapy, Combination
Middle Aged
Pentoxifylline / therapeutic use*
Polyradiculopathy / drug therapy*,  etiology
Radiation Injuries / complications
Radiation-Protective Agents / therapeutic use*
Tocopherols / therapeutic use*
Reg. No./Substance:
0/Antioxidants; 0/Radiation-Protective Agents; 10596-23-3/Clodronic Acid; 1406-66-2/Tocopherols; 6493-05-6/Pentoxifylline

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