Document Detail


Significant beneficial effect of AT-1 receptor blockers (sartans) in stroke.
MedLine Citation:
PMID:  22246005     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hypertension is the most important controllable and modifiable risk factor for stroke. The relationship between blood pressure and stroke mortality is strong and linear. Angiotensin receptor blockers (sartans) are competitive pharmacological antagonists of angiotensin II receptors, and some of them are approved for use in the treatment of hypertension. These drugs also show anti-inflammatory effects by reducing the cytokine levels. The anti-inflammatory effects of sartans play a role in reducing cerebral injury following stroke, and improve the outcome of stroke in terms of improving cognitive function. In humans, sartans are safe in hypertensive acute stroke patients and may offer advantages independent of blood pressure control. Sartans promote neovascularization and thereby provide long-term cerebro-protection in terms of vascular protection and enhancement of early angiogenic remodeling. In this review, the beneficial effects of sartans in the management of stroke are discussed, considering the results of experimental and clinical studies.
Authors:
Marwan S Al-Nimer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosciences (Riyadh, Saudi Arabia)     Volume:  17     ISSN:  1319-6138     ISO Abbreviation:  Neurosciences (Riyadh)     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101252453     Medline TA:  Neurosciences (Riyadh)     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  6-15     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Medicine, Al-Mustansiriya University, PO Box 14132, Baghdad, Iraq. Tel. +964 5591530. E-mail: alnimermarwan@ymail.com.
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