Document Detail

Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene.
MedLine Citation:
PMID:  21547701     Owner:  NLM     Status:  MEDLINE    
Systemic sclerosis (SSc) is characterized by vascular injuries, and bosentan has recently been proved to be efficacious for the prevention of new digital ulcers in SSc. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc.
Yohei Ichimura; Yoshihide Asano; Masaru Hatano; Zenshiro Tamaki; Tomonori Takekoshi; Asako Kogure; Manabu Tomita; Tomohiko Kawashima; Miki Miyazaki; Takashi Taniguchi; Takehiro Takahashi; Hiroshi Mitsui; Makoto Sugaya; Atsushi Yao; Koichiro Kinugawa; Shinichi Sato
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-03-10
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  21     ISSN:  1439-7609     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-13     Completed Date:  2012-02-07     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  548-52     Citation Subset:  IM    
Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Fingers / blood supply*,  pathology
Gangrene / drug therapy,  etiology,  pathology
Middle Aged
Regional Blood Flow / drug effects*
Scleroderma, Diffuse / complications,  drug therapy*,  pathology
Skin Ulcer / drug therapy*,  etiology,  pathology
Sulfonamides / therapeutic use*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Sulfonamides; Q326023R30/bosentan

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