| Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene. | |
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MedLine Citation:
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PMID: 21547701 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Systemic sclerosis (SSc) is characterized by vascular injuries, and bosentan has recently been proved to be efficacious for the prevention of new digital ulcers in SSc. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc. |
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Authors:
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Yohei Ichimura; Yoshihide Asano; Masaru Hatano; Zenshiro Tamaki; Tomonori Takekoshi; Asako Kogure; Manabu Tomita; Tomohiko Kawashima; Miki Miyazaki; Takashi Taniguchi; Takehiro Takahashi; Hiroshi Mitsui; Makoto Sugaya; Atsushi Yao; Koichiro Kinugawa; Shinichi Sato |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-10 |
Journal Detail:
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Title: Modern rheumatology / the Japan Rheumatism Association Volume: - ISSN: 1439-7609 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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