| Significant association of HLA-DQ5 with autoimmune hepatitis in Taiwan. | |
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MedLine Citation:
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PMID: 18194915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetic predisposition is known to be an important etiopathogenic factor of autoimmune hepatitis (AIH). HLA antigens associated with AIH have been well studied in Western countries and Japan, but there is no HLA typing data of AIH patients in Taiwan. We therefore investigated HLA phenotypes and their association with AIH patients and compared the results with those of normal subjects and patients with chronic liver disease. Group 1 consisted of 22 AIH patients. All were born in Taiwan with no history of blood transfusion. Group 2 consisted of 19 chronic liver disease patients. Group 3 consisted of 81 unrelated healthy subjects who were normal blood donors. All three groups were tested for HLA phenotypes (HLAA, B, C, DR, DQ) using the polymerase chain reaction-sequence specific probe method. The statistical method used was Fisher's exact test. We found that HLA-DQ5 was significantly more frequent in the AIH group compared to the control group (RR, 2.03; p = 0.034). Low frequency of A1 (n = 2/22), B8 (n = 1/22) and DR3 (n = 0/22) were noted compared to results from the West; only HLA-DR4 showed a higher rate in our AIH patients (n = 8/22). This is a preliminary report of our study of HLA antigens in AIH patients. Further investigation to characterize AIH patients into HLA allelic subgroups is being done. |
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Authors:
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Lok-Beng Koay; Chi-Shu Sun; Sun-Lung Tsai; Ching-Yih Lin |
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Publication Detail:
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Type: Journal Article; Retracted Publication |
Journal Detail:
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Title: Journal of the Formosan Medical Association = Taiwan yi zhi Volume: 106 ISSN: 0929-6646 ISO Abbreviation: J. Formos. Med. Assoc. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-01-15 Completed Date: 2008-02-21 Revised Date: 2008-08-06 |
Medline Journal Info:
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Nlm Unique ID: 9214933 Medline TA: J Formos Med Assoc Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 1063-8 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan. 860316@mail.chimei.org.tw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Female Genetic Predisposition to Disease HLA Antigens / genetics HLA-DQ Antigens / genetics* Hepatitis, Autoimmune / epidemiology*, genetics* Humans Male Middle Aged Phenotype Taiwan / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-DQ Antigens; 0/HLA-DQ5 antigen |
| Comments/Corrections | |
Retraction In:
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Huang LM. J Formos Med Assoc. 2008 Mar;107(3):275
[PMID:
18400615
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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