Document Detail

Significant association of HLA-B and HLA-DRB1 alleles with cleft lip with or without cleft palate.
MedLine Citation:
PMID:  10090614     Owner:  NLM     Status:  MEDLINE    
Nucleotide sequence level typing of HLA-B, -DRB1, and -DPB1 alleles was performed on Japanese patients with cleft lip with or without cleft palate (CL/P). Two HLA-B alleles, B*1501 and B*5101, showed a significant positive association with CL/P. The increase of B*1501 was evident in female patients (OR=3.6, Pc=0.003), whereas the increase of B*5101 was evident in male patients (OR=3.7, Pc < 0.001). One HLA-DRB1 allele, HLA-DRB1*0802 also showed an increase in CL/P patients. Conversely, HLA-B*4403 and DRB1*1302 were not observed in the patient group (Pc=0.01 and Pc=0.02, respectively). No HLA-DPB1 alleles showed significant association with CL/P. Thus, the present study indicates that HLA alleles, or closely linked loci, may be involved in the pathogenesis of CL/P.
Y Sakata; K Tokunaga; Y Yonehara; M Bannai; N Tsuchiya; T Susami; T Takato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  53     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Cleft Lip / genetics*
Cleft Palate / genetics*
HLA-B Antigens / genetics*
HLA-DP Antigens / genetics
HLA-DR Antigens / genetics*
Reg. No./Substance:
0/HLA-B Antigens; 0/HLA-DP Antigens; 0/HLA-DPB1; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen

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