Document Detail

Significant Reduction of Atrial Defibrillation Threshold and Inducibility by Catheter Ablation of Atrial Fibrillation.
MedLine Citation:
PMID:  22978799     Owner:  NLM     Status:  Publisher    
Background: Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) has antiarrhythmic effects by multiple mechanisms. We hypothesized that RFCA curtails atrial defibrillation threshold (A-DFT) and postablation induction pacing cycle length (iPCL), making critical mass reduction one potential mechanism by which antiarrhythmic effect is achieved. Methods: We included 289 patients with AF (male 77.9%, 55.7 ± 10.8 years old; 197 paroxysmal AF: 92 persistent AF) who underwent RFCA. A-DFT (serial internal cardioversion 2, 3, 5, 7, and 10 J) and iPCL (serial 10 mA 10-second atrial pacing with pacing cycle length 250, 200, 190, 180, 170, 160, and 150 ms) were evaluated before and after RFCA. Results: (1) RFCA of AF reduced the A-DFT from 6.7 ± 3.7 J to 3.0 ± 3.0 J (P < 0.001). (2) AF ablation reduced AF inducibility from 95.4% before the procedure to 56.3% after the procedure (P < 0.001), and the iPCL from 194.8 ± 32.6 to 160.9 ± 26.2 ms (P < 0.001). (3) In patients who underwent a greater number of ablation lines, the post-RFCA A-DFT (P < 0.001) was lower, and %ΔA-DFT (P = 0.003) and proportion of atrial tachycardia (P = 0.022) were higher than those with a lower number of ablation lines. Conclusion: AF ablation significantly reduced A-DFT, AF inducibility, and iPCL, and the degree of their reduction was related to the number of ablation lines. (PACE 2012;00:1-8).
Eui-Seock Hwang; Gi Byung Nam; Boyoung Joung; Junbeom Park; Jihei Sara Lee; Jaemin Shim; Jae-Sun Uhm; Moon Hyoung Lee; Hui-Nam Pak
Related Documents :
11015099 - All-artery multigraft coronary artery bypass grafting with only internal thoracic arter...
24120469 - Myocardial remote ischemic preconditioning: from pathophysiology to clinical application.
8227799 - Coronary artery bypass grafting in severe left ventricular dysfunction: excellent survi...
8215679 - Cardiac dilatation after cardiopulmonary bypass: ceramic plate technique for sternal sp...
1637229 - Heterotopic heart transplantation and recipient heart operation in ischemic heart disease.
15311859 - Surgery for aortic stenosis in octogenarians: influence of coronary disease and other c...
19291559 - Can paramedics read st-segment elevation myocardial infarction on prehospital 12-lead e...
3942299 - Anesthesia for hypoplastic left heart syndrome: use of high-dose fentanyl in 30 neonates.
9740349 - Pattern of left ventricular filling in hypertrophic cardiomyopathy. assessment by doppl...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-14
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  -     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc.
Yonsei University Health System, Seoul, Republic of Korea Division of Cardiology, Asan Medical Center, Ulsan University, Seoul, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An internal deletion in MTH1 enables growth on glucose of pyruvate-decarboxylase negative, non-ferme...
Next Document:  Prevalence and factors associated with nonalcoholic fatty liver disease in Shanghai work-units.