| Significant Increase in Natural-killer T Cells in Patients with Tuberculosis Complicated by Type 2 Diabetes Mellitus. | |
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MedLine Citation:
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PMID: 21672313 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study examined the frequency of Vα24(+)/Vβ11(+) natural-killer T (NKT) cells from peripheral blood and bronchoalveolar lavage fluid in pulmonary tuberculosis (TB) patients with or without diabetes mellitus (DM). The clinical grade of TB was significantly higher among diabetic patients. NKT cells from both peripheral blood and bronchoalveolar lavage were significantly increased in diabetic TB patients compared with non-diabetic TB patients. This may be due to the generally higher bacillary burden in diabetic TB patients. NKT cells from peripheral blood mononuclear cells in TB patients with or without DM were significantly increased, compared with levels in non-TB diabetic patients and healthy controls. The measurement of NKT cells from peripheral blood has the potential to be a reliable, non-invasive, practical diagnostic marker for active TB. |
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Authors:
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Q Zhang; H-P Xiao; H-Y Cui; I Sugawara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of international medical research Volume: 39 ISSN: 1473-2300 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 105-11 Citation Subset: IM |
Affiliation:
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Department of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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