Document Detail


Significance of urinary liver-fatty acid-binding protein in cardiac catheterization in patients with coronary artery disease.
MedLine Citation:
PMID:  19797828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We investigated the significance of urinary liver fatty acid-binding protein (U-L-FABP) monitoring during cardiac catheterization in patients with cardiovascular disease (CVD). Methods The subjects included 27 consecutive patients with stable angina (SAP group) or acute coronary syndrome (ACS group) who had undergone successful percutaneous coronary intervention (PCI), and 12 patients were also enrolled as controls (C group). Urinary and serum parameters were measured immediately before and after and 1 day after PCI. RESULTS: The ratio of U-L-FABP to U-creatinine (U-Cr) (U-L-FABP/U-Cr) in the ACS group was significantly higher than those in both the SAP and C groups before PCI. In addition, none of the patients in the SAP group showed contrast-induced nephropathy (CIN) based on the levels of serum (S)-Cr and U-L-FABP/U-Cr after PCI. Although none of the patients in the ACS group showed CIN according to S-Cr, the level of U-L-FABP/U-Cr was continuously high throughout the study period. Moreover, since there were significant differences in U-L-FABP/U-Cr, U-N-acetyl-beta-D-glucosaminidase, S-uric acid and % medication with calcium channel blockers before PCI between the ACS and SAP groups, a multiple regression analysis was performed using these parameters. It showed that U-L-FABP/U-Cr was most closely associated with the classification of SAP and ACS (p<0.0001). The cut-off level for the greatest sensitivity and specificity for U-L-FABP for the diagnosis of ACS was 13.4 microg/g. Cr in all subjects (sensitivity 0.800, specificity 0.963). CONCLUSIONS: To the best of our knowledge, this is the first report indicating that the measurement of U-L-FABP can be beneficial for in the diagnosis of ACS.
Authors:
Yusuke Fukuda; Shin-ichiro Miura; Bo Zhang; Atsushi Iwata; Akira Kawamura; Hiroaki Nishikawa; Kazuyuki Shirai; Keijiro Saku
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Publication Detail:
Type:  Journal Article     Date:  2009-10-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  48     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-02     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1731-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / diagnosis,  urine
Aged
Aged, 80 and over
Angina Pectoris / diagnosis,  urine
Angioplasty, Transluminal, Percutaneous Coronary
Biological Markers / urine
Case-Control Studies
Coronary Artery Disease / diagnosis*,  physiopathology,  therapy,  urine*
Creatinine / urine
Fatty Acid-Binding Proteins / urine*
Female
Glomerular Filtration Rate
Heart Catheterization*
Humans
Male
Middle Aged
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acid-Binding Proteins; 60-27-5/Creatinine

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