Document Detail


Significance of tartrazine sensitivity in chronic urticaria of unknown etiology.
MedLine Citation:
PMID:  777074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of 38 patients with chronic urticaria of unknown etiology who were evaluated for food and drug additive sensitivity, 53% (20/38) had urticaria for 1 yr or more. Total eosinophil counts were not elevated in most patients, and the frequency of atopy was found to be similar to that in a general population. Of these 38 patients, 10 (26%) had a personal history of aspirin intolerance, but elimination of aspirin did not relieve the urticaria. In a double-blind crossover challenge with 0.22 mg of tartrazine and a control, tartrazine sensitivity was found in 8% (3/38) of patients with chronic urticaria and 20% (2/10) of patients with aspirin intolerance.
Authors:
G A Settipane; F H Chafee; I M Postman; M I Levine; J H Saker; R H Barrick; S S Nicholas; H J Schwartz; R W Honsinger; D E Klein
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  57     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-23     Completed Date:  1976-08-23     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspirin / adverse effects
Azo Compounds / adverse effects*
Benzenesulfonates / adverse effects
Chronic Disease
Clinical Trials as Topic
Eosinophils
Female
Food Coloring Agents / adverse effects*
Humans
Hypersensitivity / complications
Leukocyte Count
Male
Pyrazoles / adverse effects
Urticaria / complications,  etiology*
Chemical
Reg. No./Substance:
0/Azo Compounds; 0/Benzenesulfonates; 0/Food Coloring Agents; 0/Pyrazoles; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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