| Significance of sympathetic innervation of pulmonary vessels in response to acute hypoxia. | |
| | |
MedLine Citation:
|
PMID: 893268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of the autonomic nervous system on the pulmonary vascular response to hypoxia was studied in anesthetized open-chest dogs. Acute hypoxia elicited reversible decreases in the slope of the instantaneous diameter-pressure relationship of the main pulmonary artery. These decrements in vascular compliance during hypoxia were prevented by either bilateral thoracic sympathectomy or by section of the cervical vagus and glossopharyngeal nerves and were reproduced by bolus injections of lobeline (0.1 mg) at the root of the aorta. Using separation of the airways with a tracheal divider, the effects of systemic and of alveolar hypoxia on vascular resistance of the left caudal lobe were compared. Systemic hypoxia in the absence of alveolar hypoxia had no effect on pulmonary vascular resistance. Alveolar hypoxia elicited reversible increases in vascular resistance that were not prevented by sympathectomy. It is concluded that at least two vascular sites of action and two mechanisms are involved in the pulmonary vascular response to hypoxia. |
| | |
Authors:
|
J P Szidon; J F Flint |
Related Documents
:
|
961858 - Reversal of hypoxic bradycardia by halothane or midcollicular decerebration. 2554868 - Reduced systolic blood pressure elevations during maximum exercise at simulated altitudes. 10872138 - The hemodynamic effects of prolonged respiratory alkalosis in anesthetized newborn pigl... 18935908 - Intracerebroventricular serotonin reduces the degree of acute hypoxic ventilatory depre... 20448078 - Ventilation-perfusion ratio in perflubron during partial liquid ventilation. 7950798 - Failure of normobaric oxygen therapy to reduce ischemic brain damage in rats. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 43 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1977 Jul |
Date Detail:
|
Created Date: 1977-10-28 Completed Date: 1977-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 65-71 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anoxia / physiopathology* Dogs Pulmonary Artery / innervation*, physiopathology Sympathectomy Sympathetic Nervous System / physiopathology* Vascular Resistance |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of exercise and eucapnic hyperventilation on bronchial clearance in man.
Next Document: Adaptation to short-term respiratory effects of ozone in men exposed repeatedly.