| Significance of serum bactericidal activity in gram-negative bacillary bacteremia in patients with and without granulocytopenia. | |
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MedLine Citation:
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PMID: 6702874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum bactericidal activity was determined routinely in 89 patients with gram-negative bacillary bacteremia, 79 of whom were analyzed because they had granulocyte counts either below 100/mm3 or above 1,000/mm3. A peak (one hour after the administration of the antibiotics) serum bactericidal titer of 1:8 or more in non-granulocytopenic patients or 1:16 or more in severely granulocytopenic patients could be correlated with a favorable clinical response, in 98 percent (44 of 45) (p less than 0.0001) and 87 percent (20 of 23), (p less than 0.001) respectively. Granulocytopenic patients required a statistically significantly higher serum bactericidal activity for a favorable response. Serum bactericidal activity appears to be a useful and simple method to monitor antibiotic treatment in gram-negative bacillary bacteremia, especially when combination therapy is used. |
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Authors:
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J P Sculier; J Klastersky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of medicine Volume: 76 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-04-11 Completed Date: 1984-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 429-35 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agranulocytosis
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complications* Bacterial Infections / complications, immunology* Blood Bactericidal Activity* Gram-Negative Bacteria / isolation & purification* Humans Leukemia / complications Leukocyte Count Neutropenia / complications* Outcome and Process Assessment (Health Care) |
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