Document Detail

Significance of serum bactericidal activity in gram-negative bacillary bacteremia in patients with and without granulocytopenia.
MedLine Citation:
PMID:  6702874     Owner:  NLM     Status:  MEDLINE    
Serum bactericidal activity was determined routinely in 89 patients with gram-negative bacillary bacteremia, 79 of whom were analyzed because they had granulocyte counts either below 100/mm3 or above 1,000/mm3. A peak (one hour after the administration of the antibiotics) serum bactericidal titer of 1:8 or more in non-granulocytopenic patients or 1:16 or more in severely granulocytopenic patients could be correlated with a favorable clinical response, in 98 percent (44 of 45) (p less than 0.0001) and 87 percent (20 of 23), (p less than 0.001) respectively. Granulocytopenic patients required a statistically significantly higher serum bactericidal activity for a favorable response. Serum bactericidal activity appears to be a useful and simple method to monitor antibiotic treatment in gram-negative bacillary bacteremia, especially when combination therapy is used.
J P Sculier; J Klastersky
Related Documents :
4073864 - Pharmacokinetics and tissue penetration of carumonam, a new synthetic monobactam.
7387144 - Serum and subcutaneous chamber fluid dynamics of penicillins after single large parente...
820524 - Relationships between the concentrations of doxycycline in serum and in thoracic duct l...
17704514 - Diffusion of ertapenem into bone and synovial tissues.
19320244 - A phase i study to explore the activity and safety of sch532706, a small molecule chemo...
6409774 - Serum calcium decline after intravenous administration of thyrotropin-releasing hormone...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  76     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-04-11     Completed Date:  1984-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  429-35     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Agranulocytosis / complications*
Bacterial Infections / complications,  immunology*
Blood Bactericidal Activity*
Gram-Negative Bacteria / isolation & purification*
Leukemia / complications
Leukocyte Count
Neutropenia / complications*
Outcome and Process Assessment (Health Care)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neutropenia, fever, and infection.
Next Document:  Can antibacterial therapy be discontinued in persistently febrile granulocytopenic cancer patients?