Document Detail


Significance of the pulmonary artery diastolic-pulmonary wedge pressure gradient in sepsis.
MedLine Citation:
PMID:  7116887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An initially widened pulmonary artery diastolic-pulmonary wedge pressure (PAD-PWP) gradient greater than 5 mm Hg has been reported to be associated with an 83% mortality rate in septic patients. To confirm and extend these observations, we retrospectively reviewed the charts of 47 septic patients. The patients were divided into 2 groups: group 1-12 patients who never had an abnormal gradient during their hospital course, and group 2-35 patients who had an abnormal gradient sometimes during their course. There were no hemodynamic differences. However, the mortality rate in group 2 patients was significantly higher than in group 1 patients (60% vs 25%, p less than 0.01). In patients with an initial gradient, the mortality rate was 61% which is not significantly different than the 83% previously reported. In patients with a persistent or increasing gradient before death or the resolution of sepsis, the mortality rate was 91%. We conclude that although an initial PAD-PWP gradient in patients with sepsis is associated with a high mortality, a much more sensitive indicator is whether the gradient increases or persists over time. There is a 91% mortality in patients with persisting or increasing gradients.
Authors:
A M Marland; F L Glauser
Related Documents :
18093857 - Risk assessment of acute vascular events in congenital disorder of glycosylation type ia.
12010907 - Incidence and prognostic importance of acute renal failure after percutaneous coronary ...
10686447 - Leukocyte activation: relation to cardiovascular mortality after cerebrovascular ischemia.
19522837 - Renal artery stenosis predicts adverse cardiovascular and renal outcome in patients wit...
4761607 - Lymphoblastic response to autologous colon epithelial cells in ulcerative colitis in vi...
19067227 - Effect of bh(4) supplementation on phenylalanine tolerance.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  10     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  658-61     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure*
Critical Care
Diastole
Female
Humans
Infection / physiopathology*
Male
Middle Aged
Prognosis
Pulmonary Artery
Pulmonary Wedge Pressure*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Statistical evaluation of plasma substitutes based on 10 variables.
Next Document:  Relationship between transcutaneous and arterial oxygen tension in sick neonates during mild hyperox...